Peptide-catalyzed consecutive 1,6- and 1,4-additions of thiols to α,β,γ,δ-unsaturated aldehydes.
نویسندگان
چکیده
Regio- and enantioselective addition of thiols to α,β,γ,δ-unsaturated aldehydes was performed with a resin-supported peptide catalyst. It was shown that a 1,4-adduct was generated mainly at the initial stage of the reaction, and this was eventually converted to a thermodynamically stable 1,6- and 1,4-diadduct through retro-addition/addition reactions.
منابع مشابه
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 12 22 شماره
صفحات -
تاریخ انتشار 2014